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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 7, 2014; 20(9): 2279-2303
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2279
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2279
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
Julian Swierczynski, Areta Hebanowska, Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland
Tomasz Sledzinski, Department of Pharmaceutical Biochemistry, Medical University of Gdansk, 80-211 Gdańsk, Poland
Author contributions: Swierczynski J contributed to background research, formulation of the manuscript, revision of the manuscript, and final approval of the manuscript; Hebanowska A contributed to background research, formulation of the manuscript, and revision of the manuscript; Sledzinski T contributed to background research, formulation of the manuscript, and management of images.
Supported by Medical University of Gdansk Grants ST-41, ST-40
Correspondence to: Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. juls@gumed.edu.pl
Telephone: +48-58-3491462 Fax: +48-58-3491465
Received: October 28, 2013
Revised: December 25, 2013
Accepted: January 3, 2014
Published online: March 7, 2014
Revised: December 25, 2013
Accepted: January 3, 2014
Published online: March 7, 2014
Core Tip
Core tip: Metabolic alterations associated with mutation in oncogenes and tumor suppressor genes play an important role in cancer development and progression. One of the most important aberrations of metabolism in cancer cells is an elevated synthesis of lipids, which are building blocks for cell membrane formation during cell proliferation and signalling molecules. This review aims to demonstrate the changes in lipid metabolism in pancreatic ductal adenocarcinoma, the most common pancreatic neoplasm, with very high mortality. The potential role of elevated lipid synthesis in diagnosis, prognosis and therapy of pancreatic cancer is also discussed.