Park BJ, Lee YJ, Lee HR. Chronic liver inflammation: Clinical implications beyond alcoholic liver disease. World J Gastroenterol 2014; 20(9): 2168-2175 [PMID: 24605015 DOI: 10.3748/wjg.v20.i9.2168]
Corresponding Author of This Article
Hye-Ree Lee, MD, PhD, Professor, Department of Family Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, South Korea. love0614@yuhs.ac
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Byoung-Jin Park, Department of Family Medicine, CHA University School of Medicine, Seoul 135-720, South Korea
Yong-Jae Lee, Hye-Ree Lee, Department of Family Medicine, Yonsei University College of Medicine, Seoul 135-720, South Korea
Author contributions: Park BJ and Lee YJ contributed equally to conception and design, acquisition of data, interpretation of data and drafting the article; Lee HR revised it critically for important intellectual content and all authors approved the final version to be published.
Correspondence to: Hye-Ree Lee, MD, PhD, Professor, Department of Family Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, South Korea. love0614@yuhs.ac
Telephone: +82-2-20193480 Fax: +82-2-34633287
Received: November 19, 2013 Revised: December 21, 2013 Accepted: January 14, 2014 Published online: March 7, 2014
Core Tip
Core tip: Beyond the natural course in the liver, alcoholic liver disease can be implicated in many health problems that affect the quality of life and disease progression. Evidence suggests that alcoholic liver disease is a predictor for liver-related diseases, cardiovascular disease, immunologic disease, and bone disease. Chronic inflammation in alcoholic liver disease and related systemic illness is mediated by a direct response to alcohol and an indirect inflammatory response. Alcoholic liver disease should be considered from the perspective of chronic inflammation. Accordingly, integrative therapeutic strategies including anti-inflammatory targeting are needed for alcohol-induced liver inflammation management and prevention of systemic medical problems.
