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World J Gastroenterol. Feb 21, 2014; 20(7): 1833-1838
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1833
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1833
Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review
Peter P Stanich, Samer El-Dika, Marty M Meyer, Division of Gastroenterology, Hepatology and Nutrition, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Robert Pilarski, Division of Human Genetics, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Jonathan Rock, Wendy L Frankel, Department of Pathology, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Author contributions: Stanich PP, Pilarski R and Meyer MM were involved in study creation, data collection, data interpretation and manuscript preparation and revision; Rock J, Frankel WL and El-Dika S were involved with data interpretation and critical manuscript revision.
Correspondence to: Marty M Meyer, MD, Division of Gastroenterology, Hepatology and Nutrition, the Ohio State University Wexner Medical Center, 395 West 12th Avenue, Suite 200, Columbus, OH 43210, United States. marty.meyer@osumc.edu
Telephone: + 1-614-2934191 Fax: +1-614-2938518
Received: July 28, 2013
Revised: September 12, 2013
Accepted: September 29, 2013
Published online: February 21, 2014
Revised: September 12, 2013
Accepted: September 29, 2013
Published online: February 21, 2014
Core Tip
Core tip: Phosphatase and tensin homolog on chromosome ten (PTEN) hamartoma tumor syndrome has a high rate of colonic polyposis. In contrast with prior dogma, the majority of patients will have mixed polyp histologies including adenoma, hamartoma and hyperplastic. Thus, multiple polyp types should spur investigation for this syndrome with a thorough clinical exam and possibly genetic testing. There is likely an increased risk of colorectal cancer at a young age and surveillance colonoscopy is recommended. We recommend starting at age 35 years.