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World J Gastroenterol. Feb 14, 2014; 20(6): 1614-1622
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1614
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1614
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
Jing-Yao Zhang, Yong Wan, Si-Dong Song, Jia Xu, Xin-Sen Xu, Hu-Lin Chang, Ming-Hui Tai, Chang Liu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Xi’an 710061, Shaanxi Province, China
Qi-Fei Wu, Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Xi’an 710061, Shaanxi Province, China
Ming-Hui Tai, Ya-Feng Dong, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas, KS 66160, United States
Author contributions: Zhang JY and Wu QF contributed equally to this work, who designed the research and wrote the paper; Wan Y contributed to the preparation of the paper and literature search; Song SD contributed to research design; Xu J participated in research design and revised the paper; Xu XS and Chang HL performed literature search; Tai MH performed data analysis; Dong YF advised in research design and data analysis; and Liu C advised in research design and implementation.
Correspondence to: Chang Liu, MD, PHD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University Health Science Center, 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-82653900 Fax: +86-29-82653905
Received: September 1, 2013
Revised: October 24, 2013
Accepted: December 5, 2013
Published online: February 14, 2014
Revised: October 24, 2013
Accepted: December 5, 2013
Published online: February 14, 2014
Core Tip
Core tip: Aspirin is one of the most widely used medicines, but can cause adverse side effects of gastric injury. Hydrogen has been found to have powerful anti-oxidant and anti-inflammatory effects. We investigated the protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. We found that hydrogen could alleviate the aspirin-induced gastric lesions by inhibiting the oxidative stress, inflammatory reaction and reducing the Cyclooxygenase 2 in the gastric tissues. This may provide a potential therapy for the adverse effects of aspirin.