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World J Gastroenterol. Feb 14, 2014; 20(6): 1608-1613
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1608
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1608
Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer
Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China
Li-Li Du, Yan Wang, Cun-Zhi Han, Jie-Xian Jing, Xian-Wen Zhao, Xiao-Qin Xu, Laboratory of Etiology, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China
Author contributions: Jiang B and Du LL designed the study and provided financial support for this work; Zhang X and Liu DB collected the patient material and acquired the data; Du LL, Wang Y and Han CZ performed data analysis and interpretation; Jing JX, Zhao XW and Xu XQ provided vital reagents, revised the paper critically for intellectual content and were also involved in editing the manuscript; Du LL and Han CZ wrote the manuscript.
Correspondence to: Li-Li Du, Associate Senior Technician, Laboratory of Etiology, Shanxi Cancer hospital, 3# Zhigongxinjie, Taiyuan 030013, Shanxi Province, China. 610842029@qq.com
Telephone: +86-351-4651667 Fax: +86-351-4651667
Received: September 13, 2013
Revised: December 9, 2013
Accepted: December 12, 2013
Published online: February 14, 2014
Revised: December 9, 2013
Accepted: December 12, 2013
Published online: February 14, 2014
Core Tip
Core tip: A previous study evaluated the effects of insulin, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) on cell growth and proliferation, which played important roles in the etiology of colon cancer. The present study aimed to investigate the relationship of changes in serum insulin, IGF-1, IGFBPs, body mass index, waist-to-hip ratio with the initiation and progression of colorectal cancer. We observed that there were no differences in serum levels of leptin, IGF-1, IGFBP-1 and IGFBP-3 as well as IGF-1/IGFBP-3 ratio between pre- and post-operation colorectal cancer patients.