Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2014; 20(44): 16765-16773
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16765
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16765
Xeroderma pigmentosum group D polymorphisms and esophageal cancer susceptibility: A meta-analysis based on case-control studies
Rong Yang, Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Chong Zhang, Armah Malik, Jian Hu, Yi-He Wu, Department of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Zhi-Da Shen, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang Province, China
Author contributions: Wu YH and Hu J designed the research; Yang R and Zhang C performed the research; Yang R, Malik A and Shen ZD wrote the paper.
Correspondence to: Yi-He Wu, MD, Department of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. drwuyihe@163.com
Telephone: +86-571-87236847 Fax: +86-571-87236847
Received: March 21, 2014
Revised: May 5, 2014
Accepted: July 29, 2014
Published online: November 28, 2014
Revised: May 5, 2014
Accepted: July 29, 2014
Published online: November 28, 2014
Core Tip
Core tip: To clarify the effects of xeroderma pigmentosum group D (XPD) gene polymorphisms on the risk of esophageal cancer (EC), we performed a meta-analysis of all of the case-control studies that evaluated the association between the genetic polymorphisms of XPD (Asp312Asn and Lys751Gln) and EC susceptibility. Thirteen case-control studies were recruited in the meta-analysis. For the XPD Asp312Asn polymorphism, significantly increased EC risks were found in the Asp/Asn vs Asp/Asp comparison and in the dominant model comparison. For the XPD Lys751Gln polymorphism, a significant association between the XPD Lys751Gln polymorphism and EC susceptibility was found under the recessive model.