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World J Gastroenterol. Nov 28, 2014; 20(44): 16570-16581
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16570
Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature
Jong-Min Park, Sooyeon Lee, Mi Kyung Chung, Sung-Hun Kwon, Eun-Hee Kim, Kwang Hyun Ko, Chang Il Kwon, Ki Baik Hahm
Jong-Min Park, Sooyeon Lee, Mi Kyung Chung, Sung-Hun Kwon, Eun-Hee Kim, Ki Baik Hahm, CHA Cancer Prevention Research Center, CHA University, Seoul 135-081, South Korea
Kwang Hyun Ko, Chang Il Kwon, Ki Baik Hahm, Digestive Disease Center, CHA University Bundang Medical Center, Seongnam 463-838, South Korea
Author contributions: Park JM and Lee S performed the majority of experiments; Chung MK, Kwon SH and Ko KH contributed new reagents or analytic tools for this work; Kim EH, Kwon CI and Hahm KB designed the study; Park JM and Hahm KB analyzed the data and wrote the manuscript.
Supported by The 2013 grant from the Korean Society of Ginseng funded by Korean Ginseng Cooperation
Correspondence to: Ki Baik Hahm, MD, PhD, Professor, CHA Cancer Prevention Research Center, CHA University, 605 Yeoksam 1-dong, Gangnam-gu, Seoul 135-081, South Korea. hahmkb@cha.ac.kr
Telephone: +82-2-34682869 Fax: +82-2-34682868
Received: January 8, 2014
Revised: March 10, 2014
Accepted: May 12, 2014
Published online: November 28, 2014
Core Tip

Core tip: In this review, the paradigm shift regarding the development of phytoceuticals and antioxidants is introduced following a comprehensive description of newer information pertaining to the pathogenesis of pancreatitis. Several animal models are discussed with regard to their role in efforts to develop efficient strategies against pancreatitis. Subsequently, newer therapeutic options with an emphasis on nutrients and phytoceuticals are reviewed. Further discussion also focuses on the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis, the disappointing nature of translation of these agents to clinical settings, and the expected research advances that may support the use of antioxidative phytoceuticals in the treatment of pancreatitis.