Hara N, Kawaguchi M, Takeda K, Zen Y. Retroperitoneal disorders associated with IgG4-related autoimmune pancreatitis. World J Gastroenterol 2014; 20(44): 16550-16558 [PMID: 25469023 DOI: 10.3748/wjg.v20.i44.16550]
Corresponding Author of This Article
Noboru Hara, MD, PhD, Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1, Niigata 951-8510, Japan. harasho@med.niigata-u.ac.jp
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Nov 28, 2014; 20(44): 16550-16558 Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16550
Retroperitoneal disorders associated with IgG4-related autoimmune pancreatitis
Noboru Hara, Makoto Kawaguchi, Keisuke Takeda, Yoh Zen
Noboru Hara, Keisuke Takeda, Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan
Noboru Hara, Division of Molecular Oncology, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan
Makoto Kawaguchi, Division of Diagnostic Pathology, Niigata Rousai Hospital, Niigata 951-8510, Japan
Yoh Zen, Institute of Liver Studies, King’s College Hospital, SE5 9RS London, United Kingdom
Author contributions: Hara N designed the study and wrote the manuscript; Takeda K assisted in literature searches and data acquisition; Kawaguchi M performed pathological evaluations; Zen Y was involved in editing the manuscript.
Correspondence to: Noboru Hara, MD, PhD, Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1, Niigata 951-8510, Japan. harasho@med.niigata-u.ac.jp
Telephone: +81-25-2272287 Fax: +81-25-2270784
Received: January 20, 2014 Revised: February 27, 2014 Accepted: April 28, 2014 Published online: November 28, 2014
Core Tip
Core tip: Patients with IgG4-related autoimmune pancreatitis frequently have associated conditions involving genitourinary organs. Since clinical presentations and imaging findings vary among patients, the differential diagnoses are broad. Serum IgG4 elevation is highly sensitive but not entirely specific for this condition, which is one reason why the diagnosis should be established in a multidisciplinary way. Although recent radiological advances have facilitated the effective characterization of IgG4-related retroperitoneal fibrosis, surgical resection is occasionally necessary to exclude malignancies. In addition to steroid therapy, ureteral stenting is required for patients with severe ureteral obstruction. A new concept of IgG4-related prostatitis is being increasingly recognized.
