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World J Gastroenterol. Nov 28, 2014; 20(44): 16418-16432
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16418
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16418
Rationale for the potential use of mesenchymal stromal cells in liver transplantation
Morgan Vandermeulen, Olivier Detry, Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, B4000 Liege, Wallonia, Belgium
Céline Grégoire, Yves Beguin, Department of Hematology, CHU Liege, University of Liege, B4000 Liege, Wallonia, Belgium
Alexandra Briquet, Chantal Lechanteur, Yves Beguin, Laboratory of Cell and Gene Therapy, CHU Liege, University of Liege, Sart Tilman B35, B4000 Liege, Wallonia, Belgium
Author contributions: Vandermeulen M performed the literature review and wrote the manuscript under the supervision of Beguin Y and Detry O; Grégoire C, Briquet A and Lechanteur C are responsible for the culture and production of the mesenchymal stromal cells used in the clinical study on the use of the aforementioned in liver transplantation performed at the Liege center; all authors actively reviewed the manuscript, and approved its last version.
Supported by CHU Liege, the Fonds Léon Frédéricq of the Medical School of the University of Liege, and through a Senior Research Grant from the European Society for Organ Transplantation
Correspondence to: Olivier Detry, Professor, Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Sart Tilman B35, B4000 Liege, Wallonia, Belgium. olivier.detry@transplantation.be
Telephone: +32-43-667645 Fax: +32-43-667069
Received: May 5, 2014
Revised: June 4, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Revised: June 4, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Core Tip
Core tip: For several years now, mesenchymal stromal cells (MSC) have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies, and particularly in the field of liver transplantation.