Ulcerative colitis-associated colorectal cancer

doi:10.3748/wjg.v20.i44.16389

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2014; 20(44): 16389-16397
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16389

Ulcerative colitis-associated colorectal cancer

Masakazu Yashiro

Masakazu Yashiro, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan

Masakazu Yashiro, Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan

Author contributions: Yashiro M solely contributed to the manuscript.

Correspondence to: Masakazu Yashiro, MD, PhD, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. m9312510@med.osaka-cu.ac.jp

Telephone: +81-6-66453838 Fax: +81-6-66466450

Received: May 27, 2014
Revised: September 15, 2014
Accepted: October 14, 2014
Published online: November 28, 2014

Core Tip

Core tip: Colorectal cancer (CRC) is more frequent in patients with long-term ulcerative colitis (UC), and is one of the most serious and life threatening consequences of UC. Knowledge of risk factors for CRC is important to identify UC patients who need surveillance. Colonoscopy surveillance programs are recommended to reduce the risk of CRC and mortality in UC. Genetic alterations might play a role in the development of CRC in UC patients. 5-aminosalicylates might represent a favorable therapeutic option for chemoprevention of CRC.