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World J Gastroenterol. Nov 14, 2014; 20(42): 15787-15796
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15787
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15787
Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases
Tibor Hlavaty, Anna Krajcovicova, Tomas Koller, Jozef Toth, Monika Nevidanska, Martin Huorka, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia
Juraj Payer, Department of Internal Medicine, Center for Osteoporosis and Metabolic Bone Diseases, University Hospital Bratislava, Ruzinov, 82606 Bratislava, Slovakia
Author contributions: Hlavaty T designed the study, collected the data, did the statistical analyses and wrote the manuscript; Krajcovicova A collected the data, prepared the database and reviewed the manuscript; Koller T, Toth J and Huorka M collected the data and reviewed the manuscript; Nevidanska M collected the data; and Payer J designed the study and reviewed the manuscript.
Supported by Grant from the Slovak APVV agency, No. APVV-0672-11
Correspondence to: Tibor Hlavaty, MD, PhD, Associate Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University Hospital Bratislava, Ruzinovska 6, 82606 Bratislava, Slovakia. tibor.hlavaty2@gmail.com
Telephone: +421-2-48234905 Fax: +421-2-48234905
Received: April 1, 2014
Revised: May 21, 2014
Accepted: June 13, 2014
Published online: November 14, 2014
Revised: May 21, 2014
Accepted: June 13, 2014
Published online: November 14, 2014
Core Tip
Core tip: In a cohort of 220 inflammatory bowel disease (IBD) patients, we observed that vitamin D (VD)-insufficient patients (< 30 ng/mL) had a lower health related quality of life (sIBDQ) in the winter/spring period. In all analyzed scenarios (ulcerative colitis/Crohn’s disease, the summer/autumn and the winter/spring period), the health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/mL, indicating a possible target level for therapeutic VD supplementation. Furthermore, we observed that supplementation with currently recommended doses of VD supplementation of 800 IU/d VD did not influence VD serum concentration or the sIBDQ score.