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World J Gastroenterol. Nov 14, 2014; 20(42): 15624-15631
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15624
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15624
Gut microbiota-related complications in cirrhosis
Isabel Gómez-Hurtado, José Such, Rubén Francés, CIBERehd-Liver Unit, Hospital General Universitario Alicante, Alicante 03010, Spain
Yolanda Sanz, Instituto de Agroquímica y Tecnología de los Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Carrer Catedràtic Agustín Escardino Benlloch, 7, Paterna, València 46980, Spain
Author contributions: Gómez-Hurtado I performed manuscript writing; Such J performed clinical considerations and manuscript writing; Sanz Y performed microbiological considerations and manuscript wrtitng; Francés R performed design and manuscript writing.
Supported by Grants PI13/1443 from Instituto de Salud Carlos III, Madrid, Spain; and No. AGL2011-25169 from MINECO, Madrid, Spain
Correspondence to: Rubén Francés, PhD, CIBERehd-Liver Unit, Hospital General Universitario Alicante, C/Pintor Baeza 12, Alicante 03010, Spain. frances_rub@gva.es
Telephone: +34-965-913928 Fax: +34-965-913922
Received: February 28, 2014
Revised: April 16, 2014
Accepted: May 19, 2014
Published online: November 14, 2014
Revised: April 16, 2014
Accepted: May 19, 2014
Published online: November 14, 2014
Core Tip
Core tip: The close relationship between the most frequent complications arising in patients with cirrhosis and the gut microbiota has been intensively studied in the last years and has enhanced the relevance of the constant communication between the gut and the liver in the management of patients with cirrhosis. This review intends to integrate the existing knowledge of the role of intestinal microbiota plays in the development of these complications and the evidence on the possible efficacy of gut-microbiota modulating strategies to help in their management.