Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15549
Revised: April 23, 2014
Accepted: May 19, 2014
Published online: November 14, 2014
Core tip: The recent development of stabilised contrast agents and enhancements to the endoscopic ultrasound equipment have opened an avenue for the real-time imaging of parenchymal microvascularisation without Doppler-related artefacts. Preliminary experience suggests that contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) is superior to other imaging techniques, such as EUS or computed tomography, in the differential diagnosis of pancreatic masses and other gastrointestinal diseases. In this paper, we describe the basic principles and technical aspects of performing this new technique and analyse the clinical value of CH-EUS and its potential applications in the near future.