Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15539
Revised: March 5, 2014
Accepted: April 30, 2014
Published online: November 14, 2014
Core tip: Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is the most common chronic liver disease, with a rapidly increasing prevalence worldwide. Nonalcoholic steatohepatitis (NASH), the severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. Although noninvasive clinical scores and image-based diagnosis for NAFLD have improved, histopathological evaluation of biopsy specimens remains the gold standard for diagnosing NAFLD/NASH. In this report, we review the histopathological features of NAFLD/NASH.