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World J Gastroenterol. Nov 14, 2014; 20(42): 15539-15548
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15539
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Yoshihisa Takahashi, Toshio Fukusato
Yoshihisa Takahashi, Toshio Fukusato, Department of Pathology, Teikyo University School of Medicine, Tokyo 173-8605, Japan
Author contributions: Takahashi Y wrote the manuscript; Fukusato T checked and revised the manuscript.
Correspondence to: Yoshihisa Takahashi, MD, Associate Professor, Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Telephone: +81-3-39641211 Fax: +81-3-39649622
Received: January 3, 2014
Revised: March 5, 2014
Accepted: April 30, 2014
Published online: November 14, 2014
Core Tip

Core tip: Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is the most common chronic liver disease, with a rapidly increasing prevalence worldwide. Nonalcoholic steatohepatitis (NASH), the severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. Although noninvasive clinical scores and image-based diagnosis for NAFLD have improved, histopathological evaluation of biopsy specimens remains the gold standard for diagnosing NAFLD/NASH. In this report, we review the histopathological features of NAFLD/NASH.