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World J Gastroenterol. Nov 14, 2014; 20(42): 15467-15475
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15467
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15467
Hepatitis C virus-mediated angiogenesis: Molecular mechanisms and therapeutic strategies
Mohamed Hassan, Abdelouahid El-Khattouti, Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, United States
Mohamed Hassan, Denis Selimovic, Youssef Haikel, Institut National de la Santé et de la Recherché Médicale, S 1121, Hospitals of Hautepierre, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France
Mohamed Hassan, Denis Selimovic, Youssef Haikel, Department of Operative Dentistry and Endodontics, Hospitals of Hautepierre, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France
Martine Soell, Department of Periodontology, Hospitals of Hautepierre, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France
Hanan Ghozlan, Department of Microbiology, Faculty of Science, Medical research Institute, University of Alexandria, Alexandria 21552, Egypt
Ola Abdelkader, Department of Microbiology, Medical research Institute, University of Alexandria, Alexandria 21552, Egypt
Mosaad Megahed, Clinic of Dermatology, University Hospital of Aachen, 52074 Aachen, Germany
Author contributions: All authors contributed to the manuscript.
Supported by Grant from German Research Foundation, No. HA 5081/3-1; German cancer foundation, No. 10-2202-Ha1; and L'Alsace contre le Cancer, France (to Hassan M)
Correspondence to: Mohamed Hassan, PhD, Cancer Institute, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. dr.hassan@gmx.de
Telephone: +1-601-8158945 Fax: +1-601-8158945
Received: November 7, 2013
Revised: March 24, 2014
Accepted: May 19, 2014
Published online: November 14, 2014
Revised: March 24, 2014
Accepted: May 19, 2014
Published online: November 14, 2014
Core Tip
Core tip: This editorial elaborate the molecular mechanisms of hepatitis C virus (HCV)-mediated angiogenesis and its mechanisms, and the potential of angiogenic pathways as target for hepatocellular carcinoma therapy. We summarized the current knowledge of HCV-mediated angiogenesis and the possible therapeutic strategies.