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MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines
Richard Hummel, Corina Sie, David I Watson, Tingting Wang, Alfiya Ansar, Damian J Hussey, Department of Surgery, Flinders University, Bedford Park, South Australia 5042, Australia
Richard Hummel, Department of General and Visceral Surgery, University of Muenster, 48149 Muenster, Germany
Michael Z Michael, Department of Gastroenterology and Hepatology, Flinders University, 5042 Bedford Park, South Australia, Australia
Mark Van der Hoek, Adelaide Microarray Centre, SA Pathology, 5000 Adelaide, South Australia, Australia
Joerg Haier, Comprehensive Cancer Centre, University of Muenster, 48149 Muenster, Germany
Author contributions: Hummel R participated in the conception of the study and in its design and coordination, established the chemotherapy resistant cell lines; Hummel R, Sie C, Wang T, Ansar A, Van der Hoek M and Hussey DJ conducted microarray and quantitative real-time PCR experiments for miRNA and mRNA expression analyses, performed the statistical analyses; Hummel R, Watson DI, Michael MZ, Van der Hoek M, Haier J and Hussey DJ participated in the conception of the study and in its design and coordination, participated in the interpretation of data, and helped to draft the manuscript; Wang T established the chemotherapy resistant cell lines; all authors read, revised and approved the final manuscript.
Supported by A Research Fellowship of the German Research Foundation (DFG) to Hummel R, No. Hu 1763/1-1; Funding was also obtained from a project grant from the National Health and Medical Research Council of Australia No.595964; Funding Sources (DFG, National Health and Medical Research Council of Australia)
Correspondence to: Damian J Hussey, PhD, Department of Surgery, Flinders University, Room 3D213, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia. email@example.com
Telephone: +61-8-82046086 Fax: +61-8-82046130
Received: March 5, 2014
Revised: May 19, 2014
Accepted: June 26, 2014
Published online: October 28, 2014