Zhao XK, Cheng ML, Wu RM, Yao YM, Mu M, Zhu JJ, Zhang BF, Zhou MY. Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats. World J Gastroenterol 2014; 20(40): 14875-14883 [PMID: 25356047 DOI: 10.3748/wjg.v20.i40.14875]
Corresponding Author of This Article
Ming-Liang Cheng, MD, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. chengml@21cn.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xue-Ke Zhao, Ming-Liang Cheng, Yu-Mei Yao, Mao Mu, Juan-Juan Zhu, Bao-Fang Zhang, Ming-Yu Zhou, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China
Rong-Min Wu, Department of B Ultrasound, Maternal and Child Health Hospital of Guizhou Province, Guiyang 550003, Guizhou Province, China
Author contributions: Cheng ML designed the study; Zhao XK, Wu RM, and Yao YM carried out most of the experiments and wrote the article; and all authors contributed to the design and interpretation of the study.
Supported by The Science and Technology Project of Guizhou Province, China, No. SZ [2008] 3049
Correspondence to: Ming-Liang Cheng, MD, Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. chengml@21cn.com
Telephone: +86-851-6752795 Fax: +86-851-6741623
Received: April 30, 2014 Revised: June 25, 2014 Accepted: July 16, 2014 Published online: October 28, 2014
Core Tip
Core tip: Hepatic fibrosis, as a refractory disease, represents a current threat to global health. To date, no ideal drug therapies have been identified, and drugs for liver fibrosis remain in the exploratory stage of development. Previous experimental and clinical studies showed that Danshao Huaxian capsule (DHC, originally called Handan Ganle) demonstrated efficacy in treating liver fibrosis. In this study, the effect of DHC on the expression of Gremlin and bone morphogenetic protein 7 (BMP-7) in a liver fibrosis rat model was observed to explore its potential mechanism for treating liver fibrosis. We found that the therapeutic mechanism of DHC for hepatic fibrosis in rats may be associated with inhibition of the expression of Gremlin and up-regulation of the expression of BMP-7.
