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World J Gastroenterol. Oct 28, 2014; 20(40): 14568-14580
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14568
Non-invasive assessment of liver fibrosis in chronic hepatitis B
Federica Branchi, Clara Benedetta Conti, Alessandra Baccarin, Pietro Lampertico, Dario Conte, Mirella Fraquelli
Federica Branchi, Clara Benedetta Conti, Alessandra Baccarin, Dario Conte, Mirella Fraquelli, Second Division of Gastroenterology, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy
Pietro Lampertico, First Division of Gastroenterology, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy
Author contributions: Branchi F designed research, performed research, wrote the manuscript; Conti CB performed research, wrote the manuscript; Baccarin A performed research, wrote the manuscript; Lampertico P designed research, wrote the manuscript; Conte D designed research, wrote the manuscript; Fraquelli M designed research, performed research, wrote the manuscript; all authors approved the paper.
Correspondence to: Mirella Fraquelli, MD, PhD, Second Division of Gastroenterology, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Via Francesco Sforza 35, 20122 Milano, Italy. mfraquelli@yahoo.it
Telephone: +39-2-55033445 Fax: +39-2-55033747
Received: November 17, 2013
Revised: January 10, 2014
Accepted: June 2, 2014
Published online: October 28, 2014
Core Tip

Core tip: Several non-invasive techniques for the assessment of liver disease severity, including transient elastography and serological markers, have been developed to overcome the limitations and invasivity of liver biopsy. The application of these techniques in the setting of hepatitis B viral disease for both the assessment of liver fibrosis and the prediction of liver-related complications can lead to improved patient management.