Research Report
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World J Gastroenterol. Oct 21, 2014; 20(39): 14442-14449
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14442
Effect of intra-arterial infusion with triolein emulsion on rabbit liver
Yong-Woo Kim, Young Mi Park, Sik Yoon, Hak Jin Kim, Do Yoon Park, Byung Mann Cho, Seon Hee Choi
Yong-Woo Kim, Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University College of Medicine, Yangsan 626-770, South Korea
Young Mi Park, Department of Radiology, Busan Paik Hospital, Inje University, Pusan 614-735, South Korea
Sik Yoon, Department of Anatomy, Pusan National University, College of Medicine and Biomedical Research Institute, Pusan 602-739, South Korea
Hak Jin Kim, Department of Radiology, Pusan National University, College of Medicine and Biomedical Research Institute, Pusan 602-739, South Korea
Do Yoon Park, Department of Pathology, Pusan National University, College of Medicine and Biomedical Research Institute, Pusan 602-739, South Korea
Byung Mann Cho, Preventive Medicine, Pusan National University, College of Medicine and Biomedical Research Institute, Pusan 602-739, South Korea
Seon Hee Choi, Pusan National University Postgraduate School, Pusan National University, Pusan 602-739, South Korea
Author contributions: Kim YW, Kim HJ and Yoon S designed the research; Kim YW, Kim HJ, Park YM and Choi SH performed the research and acquired the data; Yoon S, Park DY, Cho BM, Kim YW and Kim HJ analyzed and interpreted the data; Kim YW, Kim HJ and Yoon S wrote the paper; Yoon S, Park YM, Cho BM, Kim YW, Kim HJ and Park DY revised the manuscript critically for important intellectual content and approved the final version for submission.
Correspondence to: Sik Yoon, MD, Department of Anatomy, Pusan National University, College of Medicine and Biomedical Research Institute, 179, Gudeokro, Seo-Ku, Pusan 602-739, South Korea. sikyoon@pusan.ac.kr
Telephone: +82-51-2407371 Fax: +82-51-2447534
Received: March 12, 2014
Revised: June 27, 2014
Accepted: July 22, 2014
Published online: October 21, 2014
Core Tip

Core tip: Unlike triolein bolus, the infusion of triolein emulsion into a liver did not lead to mechanical obstruction of the vessels. In fact, triolein emulsion transiently and reversibly increased the vascular permeability, while triolein bolus induced obstruction similar to the fat embolism syndrome. This result suggests that trioleincould be applicable for adjuvant treatment for intractable diseases due to blood barriers (blood-brain, blood-retinal, or blood-testis barrier). This study aimed to determine potential side effects of triolein emulsion infusion into the liver with the sinusoidal capillary prior to the application of the technique in the organs with blood barrier.