Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14420
Revised: April 17, 2014
Accepted: May 25, 2014
Published online: October 21, 2014
Core tip: Corticotropin-releasing factor (CRF) and urocortin 1 (UCN1) play critical roles in many stress-related intestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. However, little is known about the pathophysiology of these diseases. To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation, human peripheral blood monocyte-derived dendritic cells were stimulated by commensal bacterial strains. Both CRF and UCN1 were significantly augmented by Bacteroides vulgatus (B. vulgatus) and Fusobacterium varium (F. varium) at both the mRNA and protein levels. Thus, B. vulgatus and F. varium may be associated with stress-related intestinal disorders.