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World J Gastroenterol. Oct 21, 2014; 20(39): 14315-14328
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14315
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14315
Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus
Eng-Hong Pok, Division of Upper GI Surgery, Department of Surgery, University Malaya Medical Center, University of Malaya, Kuala Lumpur 50603, Malaysia
Wei-Jei Lee, Department of Surgery, Min-Sheng General Hospital, National Taiwan University, Taoyuan 33044, Taiwan
Author contributions: Pok EH and Lee WJ designed and wrote the paper; Pok EH performed the literature search and wrote the paper; Pok EH and Lee WJ contributed equally.
Correspondence to: Wei-Jei Lee, MD, PhD, Department of Surgery, Min-Sheng General Hospital, National Taiwan University. No. 168, Chin Kuo Road, Taoyuan 33044, Taiwan. wjlee_obessurg_tw@yahoo.com.tw
Telephone: +886-3-3179599 Fax: +886-3-3469291
Received: November 28, 2013
Revised: March 7, 2014
Accepted: May 29, 2014
Published online: October 21, 2014
Revised: March 7, 2014
Accepted: May 29, 2014
Published online: October 21, 2014
Core Tip
Core tip: The success of bariatric surgery in obese diabetic individuals [body mass index, body mass index (BMI) > 35 kg/m2] has led to the paradigm of metabolic surgery for the treatment of type 2 diabetes mellitus, including patients with a BMI < 35 kg/m2. The mechanisms of metabolic gastrointestinal surgery are thought to depend on the dramatic entero-hormonal changes after physio-anatomical re-arrangement of the gastrointestinal tract. However, data have shown that weight loss is still the cornerstone of diabetes remission. This review will discuss the current recommendations regarding the use of gastrointestinal surgery for glycemic and metabolic control in diabetic individuals with a BMI < 35 kg/m2.