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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2014; 20(37): 13512-13520
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13512
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13512
Review of experimental attempts of islet allotransplantation in rodents: Parameters involved and viability of the procedure
Leandro Ryuchi Iuamoto, Alberto Meyer, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Sao Paulo 05403-090, Brazil
Author contributions: Iuamoto LR and Meyer A read all the articles, selected the most relevant of them and edited the manuscript; Chaib E and D’Albuquerque LAC designed the study and were also involved in editing the manuscript; all authors contributed to the manuscript.
Correspondence to: Dr. Leandro Ryuchi Iuamoto, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar 255, Sao Paulo 05403-090, Brazil. leandro.iuamoto@gmail.com
Telephone: +55-11-30618322 Fax: +55-11-30618322
Received: March 7, 2014
Revised: May 3, 2014
Accepted: June 21, 2014
Published online: October 7, 2014
Revised: May 3, 2014
Accepted: June 21, 2014
Published online: October 7, 2014
Core Tip
Core tip: This is an important systematic review for readers to analyze the different existing methodologies of islet allotransplantation. This article reviews all aspects of donors and recipients, the types and dosages of immunosuppressive therapy, graft survival time and evolution of the recipient’s blood glucose. Therefore, the present article permits reproduction and improvement of the experiments involving islet allotransplantation in rodents to develop alternative therapies for type 1 diabetes.