Ko SH, Lim CH, Kim JY, Kang SH, Baeg MK, Oh HJ. Case of inappropriate ADH syndrome: Hyponatremia due to polyethylene glycol bowel preparation. World J Gastroenterol 2014; 20(34): 12350-12354 [PMID: 25232272 DOI: 10.3748/wjg.v20.i34.12350]
Corresponding Author of This Article
Chul-Hyun Lim, MD, PhD, Assistant Professor, Division of Gastroenterology, Department of Internal medicine, College of Medicine, The Catholic University of Korea, # 505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. diluck@catholic.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
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World J Gastroenterol. Sep 14, 2014; 20(34): 12350-12354 Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12350
Case of inappropriate ADH syndrome: Hyponatremia due to polyethylene glycol bowel preparation
Sun-Hye Ko, Chul-Hyun Lim, Jae-Young Kim, Seung Hun Kang, Myong Ki Baeg, Hyun Jin Oh
Sun-Hye Ko, Hyun Jin Oh, Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University, Seoul 137-701, South Korea
Chul-Hyun Lim, Jae-Young Kim, Seung Hun Kang, Myong Ki Baeg, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Author contributions: Kim JY, Kang SH, Baeg MK and Oh HJ were the attending physicians; Ko SH oversaw the endocrinologic evaluation; Ko SH, Lim CH and Baeg MK wrote the paper.
Correspondence to: Chul-Hyun Lim, MD, PhD, Assistant Professor, Division of Gastroenterology, Department of Internal medicine, College of Medicine, The Catholic University of Korea, # 505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. diluck@catholic.ac.kr
Telephone: +82-2-22582045 Fax: +82-2-22582055
Received: January 14, 2014 Revised: March 23, 2014 Accepted: May 23, 2014 Published online: September 14, 2014
Core Tip
Core tip: We report a case of hyponatremia resulting in seizures after precolonoscopic polyethylene glycol cleansing due to inappropriate antidiuretic hormone (ADH) syndrome. Though inappropriate ADH syndrome has been suspected in the few reports of hyponatremia after polyethylene glycol (PEG) preparation, this is the first case to have confirmed an association between the two. Guidelines recommend that colonoscopic screening be done in patients from age 50 with PEG the first choice for bowel cleansing. As colonoscopic screening increases, hyponatremia due to inappropriate ADH syndrome will most likely increase as well. As we show, PEG induced inappropriate ADH syndrome may have severe side effects. However, if recognized and treated, it should have no long-lasting sequalae.
