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World J Gastroenterol. Sep 14, 2014; 20(34): 12322-12329
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12322
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12322
Effectiveness of nonsteroidal anti-inflammatory drugs in prevention of post-ERCP pancreatitis: A meta-analysis
Xiao Li, Li-Ping Tao, Chun-Hui Wang, Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wang CH and Li X designed the study; Tao LP and Li X analyzed the available data and assessed the quality of each study in accordance with pre-determined criteria; Li X performed the literature search and wrote the manuscript; all authors have read and approved the final manuscript.
Correspondence to: Chun-Hui Wang, MD, Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Wuhou District, Chengdu 610041, Sichuan Province, China. dwangsc@sina.com
Telephone: +86-28-85422385 Fax: +86-28-85422385
Received: January 19, 2014
Revised: March 10, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Revised: March 10, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Core Tip
Core tip: This meta-analysis was designed to compare the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in the presence or absence of prophylactic nonsteroidal anti-inflammatory drug (NSAID) administration after ERCP. A total of eight studies were included in the pooled analysis and contained 1883 patients that underwent ERCP with 971 patients in the NSAID group and 912 patients in the control group. Patients receiving NSAIDs after ERCP had a reduced incidence of PEP when compared with the placebo group, though NSAID administration did not reduce the incidence of moderate to severe pancreatitis.