Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2014; 20(34): 12313-12321
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12313
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12313
Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: A meta-analysis
Li-Fu Li, Zheng-Jie Wei, Hong Sun, Bo Jiang, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Li LF and Wei ZJ contributed equally to this study; Li LF designed the study and wrote the manuscript; Li LF and Wei ZJ performed the majority of analyses; Sun H and Jiang B revised the manuscript.
Correspondence to: Bo Jiang, MD, Professor, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. lilifunanfang@foxmail.com
Telephone: +86-20-61641532 Fax: +86-20-61641532
Received: February 18, 2014
Revised: April 3, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Revised: April 3, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Core Tip
Core tip:β-catenin is involved in the development of multiple tumors. It has been proved that β-catenin is important in cell-to-cell adhesion and the progression of gastric cancer. This meta-analysis demonstrated that abnormal β-catenin expression was associated with poor prognosis in patients with gastric cancer, and may predict invasion and metastasis.