Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12301
Revised: May 15, 2014
Accepted: June 12, 2014
Published online: September 14, 2014
Core tip: The global standard of care for treating acute gastroenteritis in children is 5-10 d of oral rehydration therapy, which saves lives and may reduce the duration of the illness by 20%. In this double-blind, placebo-controlled clinical study, 60% of subjects treated with a novel polyphenol-based prebiotic experienced their last unformed stool within 2 h vs 25% of the placebo treated subjects, and 89% within 24 h vs 38% of the placebo treated group. This represents a potentially extraordinary advance in the clinical management of acute gastroenteritis. If these results can be confirmed in additional studies with different populations, this treatment should become the new global standard of care.