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World J Gastroenterol. Sep 14, 2014; 20(34): 12292-12300
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12292
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12292
Amifostine enhances the antioxidant and hepatoprotective effects of UW and HTK preservation solutions
Sami Akbulut, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Turgut Ozal Medical Center, Malatya 44280, Turkey
Sinasi Sevmis, Hamdi Karakayali, Department of Surgery and Organ Transplantation, Medipol University Faculty of Medicine, Medipol Mega Hospital, Istanbul 34214, Turkey
Nilüfer Bayraktar, Department of Biochemistry, Baskent University Faculty of Medicine, Ankara 06810, Turkey
Muge Unlukaplan, Department of Pathology, Darica Farabi State Hospital, Kocaeli 41700, Turkey
Ergun Oksuz, Family Medicine Unit, Medicosocial Health Center, Baskent University Faculty of Medicine, Ankara 06810, Turkey
Atilla Dagdeviren, Department of Histology and Embryology, Baskent University Faculty of Medicine, Ankara 06810, Turkey
Author contributions: The experiments proposed in this study are derived from the thesis work of Akbulut S; Sevmis S and Karakayali H advised the thesis of Akbulut S; Akbulut S and Sevmis S performed all experiments and surgical procedures; Akbulut S wrote the paper and reviewed the literature; Unlukaplan M provided the histopathological information; Dagdeviren A provided the electron microscopy information; Bayraktar N provided biochemical information; Oksuz E performed all statistical analyses.
Correspondence to: Sami Akbulut, Associate Professor, FICS, FACS, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Turgut Ozal Medical Center, Malatya 44280, Turkey. akbulutsami@gmail.com
Telephone: +90-422-3410660 Fax: +90-422-3410036
Received: November 20, 2013
Revised: March 7, 2014
Accepted: April 28, 2014
Published online: September 14, 2014
Revised: March 7, 2014
Accepted: April 28, 2014
Published online: September 14, 2014
Core Tip
Core tip: Preserving liver tissue obtained from a donor until implantation is a critical step that affects how the graft will function. Many different organ preservation solutions have been introduced over the last quarter century, and histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) are currently the most commonly used solutions in clinical practice. Because neither the HTK nor UW solution is ideal, many studies have focused on methods to enhance the antioxidant and cytoprotective effects of the preservation solutions. In this study, we investigated whether amifostine could boost the antioxidant and cytoprotective effects of HTK and UW preservation solutions.