Günaltay S, Nyhlin N, Kumawat AK, Tysk C, Bohr J, Hultgren O, Hörnquist EH. Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis. World J Gastroenterol 2014; 20(34): 12249-12259 [PMID: 25232259 DOI: 10.3748/wjg.v20.i34.12249]
Corresponding Author of This Article
Sezin Günaltay, MSc, Department of Biomedicine, School of Health and Medical Sciences, Örebro University, SE-701 82 Örebro, Sweden. sezin.gunaltay@oru.se
Research Domain of This Article
Immunology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 14, 2014; 20(34): 12249-12259 Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12249
Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis
Sezin Günaltay, Nils Nyhlin, Ashok Kumar Kumawat, Curt Tysk, Johan Bohr, Olof Hultgren, Elisabeth Hultgren Hörnquist
Sezin Günaltay, Ashok Kumar Kumawat, Elisabeth Hultgren Hörnquist, Department of Biomedicine, School of Health and Medical Sciences, Örebro University, SE-701 82 Örebro, Sweden
Nils Nyhlin, Curt Tysk, Johan Bohr, Department of Medicine, Division of Gastroenterology, Örebro University Hospital, School of Health and Medical Sciences, Örebro University, SE-701 85 Örebro, Sweden
Olof Hultgren, Department of Microbiology and Immunology, Örebro University Hospital, SE-701 85 Örebro, Sweden
Author contributions: Günaltay S carried out the experiments, analyzed the data, and drafted the manuscript; Günaltay S and Kumawat AK prepared the patient biopsies; Nyhlin N, Bohr J and Tysk C recruited the patients and performed the colonoscopies; Günaltay S, Hultgren-Hörnquist E, Hultgren O and Nyhlin N participated in the creation of the study design, coordination, and data analysis; Hultgren Hörnquist E and Hultgren O participated in finalization of the study design and of the manuscript; all authors read and approved the final manuscript.
Supported by Research Committee of Örebro County Council; Sezin Günaltay´s salary is covered by a grant from Örebro University
Correspondence to: Sezin Günaltay, MSc, Department of Biomedicine, School of Health and Medical Sciences, Örebro University, SE-701 82 Örebro, Sweden. sezin.gunaltay@oru.se
Telephone: +46-19-302192 Fax: +46-19-6026650
Received: October 23, 2013 Revised: February 14, 2014 Accepted: April 30, 2014 Published online: September 14, 2014
Core Tip
Core tip: Epithelial destruction is observed in both microscopic and ulcerative colitis, likely resulting in enhanced contact between gut microbiota and Toll-like receptors (TLRs), which do not normally face the lumen. Insufficiently regulated TLR signaling may result in chronic inflammation. In this study, we analyzed several important regulatory molecules of TLR signaling: interleukin-1 receptor-associated kinase (IRAK)-2, IRAK-M, interleukin (IL)-37, microRNA (miR)-146a, miR-155, and miR-21. A possible association between the regulatory effects of IRAK-M and miR-146a was revealed in both diseases. This novel analysis of miR-155 and miR-21 in microscopic and ulcerative colitis revealed different expressions in active disease and remission.
