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World J Gastroenterol. Sep 14, 2014; 20(34): 12212-12216
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12212
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12212
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population
Richard Keld, Manyi Thian, Chia Hau, Jamil Sajid, Narveen Kumar, Yeng Ang, Department of Gastroenterology, Royal Albert Edward Infirmary, Wigan, Lancashire WN1 2NN, United Kingdom
Yeng Ang, Faculty of Human and Medical Sciences, University of Manchester, Manchester, Salford M6 8HD, United Kingdom
Author contributions: Keld R and Ang Y contributed to the ideas; Keld R, Thian M, Hau C, Sajid J, Kumar N and Ang Y performed the research; Keld R, Thian M and Ang Y wrote the paper.
Supported by Endowment funds of the Wrightington, Wigan and Leigh NHS Foundation Trust; Ang Y received support from Comprehensive Local Research Network of Greater Manchester and Cheshire, United Kingdom (flexibility and sustainability grant)
Correspondence to: Yeng Ang, Consultant Gastroenterologist and Honorary Senior Lecturer, Faculty of Human and Medical Sciences, University of Manchester, Manchester, Stott Lane, Salford M6 8HD, United Kingdom. yeng.ang@srft.nhs.uk
Telephone: +44-161-2065798 Fax: +44-161-2065798
Received: January 10, 2014
Revised: March 20, 2014
Accepted: May 12, 2014
Published online: September 14, 2014
Revised: March 20, 2014
Accepted: May 12, 2014
Published online: September 14, 2014
Core Tip
Core tip: Our paper is the first Western population study and shows that methylene tetra-hydrofolatereductase (MTHFR) C677T polymorphisms is not associated with risk of oesophageal adenocarcinoma in contrast to Chinese and perhaps Far East populations. This highlights the difference in terms of the biology, genetics and epigenetics between Western and Eastern cancer populations and adds to our understanding of the etiology of oesophagogastric cancers.