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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2014; 20(34): 12102-12117
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12102
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12102
Infectious etiopathogenesis of Crohn’s disease
Jessica Carrière, Arlette Darfeuille-Michaud, Hang Thi Thu Nguyen, Clermont Université, M2iSH, UMR 1071 Inserm/University of Auvergne, 63001 Clermont-Ferrand, France
Jessica Carrière, Arlette Darfeuille-Michaud, Hang Thi Thu Nguyen, INRA USC 2018, 63000 Clermont-Ferrand, France
Arlette Darfeuille-Michaud, Centre Hospitalier Universitaire, 63000 Clermont-Ferrand, France
Author contributions: Carrière J and Nguyen HTT wrote the manuscript. Darfeuille-Michaud A reviewed and edited the manuscript.
Supported by Ministère de la Recherche et de la Technologie, Inserm (UMR1071), INRA (USC-2018); Grants from the Association François Aupetit (to Darfeuille-Michaud A); and the European Union FP7 People Marie Curie International Incoming Fellowship (to Nguyen HTT)
Correspondence to: Hang Thi Thu Nguyen, PhD, Clermont Université, M2iSH, UMR 1071 Inserm/University of Auvergne, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France. hang.nguyen@udamail.fr
Telephone: +33-4-73178372 Fax: +33-4-73178371
Received: February 26, 2014
Revised: April 18, 2014
Accepted: May 25, 2014
Published online: September 14, 2014
Revised: April 18, 2014
Accepted: May 25, 2014
Published online: September 14, 2014
Core Tip
Core tip: Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract of which the etiopathogenesis is not fully understood. Increasing evidence has shown that the etiology of CD is multifactorial involving genetic, environmental and infectious factors. A dysbiosis with an increase in the abundance of putative pathogenic bacteria and a decrease in that of potentially beneficial bacteria has been observed in CD patients, revealing the involvement of intestinal microbiota in such disease. This review aims to summarize the current knowledge of the infectious etiology of CD and to discuss therapeutic approaches to modulate intestinal dysbiosis and to target CD-associated pathogens.