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World J Gastroenterol. Sep 14, 2014; 20(34): 11977-11984
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11977
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11977
Proteinase activated-receptors-associated signaling in the control of gastric cancer
Silvia Sedda, Irene Marafini, Roberta Caruso, Francesco Pallone, Giovanni Monteleone, Dipartimento di Medicina dei Sistemi, Università Tor Vergata, 00133 Rome, Italy
Author contributions: Sedda S, Marafini I, Caruso R, Pallone F and Monteleone G equally contributed to this paper; all authors read and approved the final manuscript.
Correspondence to: Giovanni Monteleone, MD, PhD, Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. gi.monteleone@med.uniroma2.it
Telephone: +39-6-72596158 Fax: +39-6-72596391
Received: December 4, 2013
Revised: February 10, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Revised: February 10, 2014
Accepted: April 30, 2014
Published online: September 14, 2014
Core Tip
Core tip: In recent years, a large body of evidence has been accumulated to support the role of proteinase activated-receptors (PARs) in the control of gastric cancer (GC). In particular, it has been demonstrated that both PAR-1 and PAR-2 may trigger intracellular signals which ultimately sustain gastric carcinogenesis, whereas the exact role of PAR-3 and PAR-4 in the initiation and progression of GC remains to be ascertained. Despite these promising and novel observations, further experimentation is needed to better characterize the mechanisms underlying the expression and function of PARs in GC and their potential as therapeutic targets.