Microarray analysis in gastric cancer: A review

doi:10.3748/wjg.v20.i34.11972

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2014; 20(34): 11972-11976
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11972

Microarray analysis in gastric cancer: A review

Giovanna D’Angelo, Teresa Di Rienzo, Veronica Ojetti

Giovanna D’Angelo, Teresa Di Rienzo, Veronica Ojetti, Department of Internal Medicine and Gastroenterology, Catholic University, 00168 Rome, Italy

Author contributions: D’Angelo G designed and wrote the article; Di Rienzo T analysed literature data and wrote the paper; Ojetti V designed, draft and revised the article.

Correspondence to: Ojetti Veronica, MD, PhD, Department of Internal Medicine and Gastroenterology, Catholic University, Largo A Gemelli 1, 00168 Rome, Italy. veronica.ojetti@tin.it

Telephone: +39-6-30156018 Fax: +39-6-30155923

Received: November 17, 2013
Revised: February 27, 2014
Accepted: April 21, 2014
Published online: September 14, 2014

Core Tip

Core tip: Gastric cancer remains one of the most common malignancies worldwide and has a poor prognosis. Early diagnosis is a key factor in improving the survival rate. No reliable diagnostic biomarker exists for gastric cancer. DNA microarray analysis is one of the new technologies able to measure the expression levels of a large number of genes simultaneously. Specific genes (differently up- or down-regulated) play an important role in the development and progression of gastric cancer. Another recent application of microarray analysis in gastric cancer is the possible tailoring of personalized chemotherapy.