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World J Gastroenterol. Sep 14, 2014; 20(34): 11939-11949
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11939
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.11939
Helicobacter pylori vaccination: Is there a path to protection?
Florian Anderl, Markus Gerhard, Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich 81675, Germany
Author contributions: Anderl F and Gerhard M wrote this review.
Correspondence to: Markus Gerhard, MD, Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstrasse 30, Munich 81675, Germany. markus.gerhard@tum.de
Telephone: +49-89-41402477 Fax: +49-89-41404139
Received: September 29, 2013
Revised: March 31, 2014
Accepted: May 19, 2014
Published online: September 14, 2014
Revised: March 31, 2014
Accepted: May 19, 2014
Published online: September 14, 2014
Core Tip
Core tip:Helicobacter pylori (H. pylori) is a carcinogenic pathogen colonizing the human stomach. In the advent of rising antibiotic resistance, it is of major interest to introduce novel therapies. Immunization is a potent candidate although all efforts to generate an effective vaccine have failed as yet. The host-pathogen interaction and especially the immune-modulating capacity of H. pylori contribute to this development of resistance to treatment. In this review potential solutions with a focus on the immune response to the pathogen are discussed.