Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

doi:10.3748/wjg.v20.i33.11753

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Sep 7, 2014; 20(33): 11753-11761
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11753

Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

Ho Hyun Nam, Dae Won Jun, Hye Joon Jeon, Jai Sun Lee, Waqar Khalid Saeed, Eun Kyung Kim

Ho Hyun Nam, Dae Won Jun, Jai Sun Lee, Department of Translational Medicine, Hanyang University Graduate School of Biomedical Science and Engineering, Seoul 133-791, South Korea

Dae Won Jun, Hye Joon Jeon, Waqar Khalid Saeed, Department of Internal Medicine, Hanyang University School of Medicine, Seoul 133-791, South Korea

Eun Kyung Kim, Department of Pathology, Eulji University College of Medicine, Seoul 139-872, South Korea

Author contributions: Jun DW had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; Nam HH, Jun DW and Saeed WK conceived and designed the study; Nam HH, Jeon HJ and Lee JS provided animal care and molecular work; Kim EK performed histological data analysis; Saeed WK provided English editing and writing.

Supported by Research fund of the National Research Foundation of Korea 2011-0007127

Correspondence to: Dae Won Jun, MD, Department of Internal Medicine, Hanyang University School of Medicine, Hangdang dong 17,133-070, Seongdong-gu, Seoul 133-791, South Korea. noshin@hanyang.ac.kr

Telephone: +82-2-22908334 Fax: +82-2-22989183

Received: November 6, 2013
Revised: January 15, 2014
Accepted: May 19, 2014
Published online: September 7, 2014

Core Tip

Core tip: Nonalcoholic fatty liver disease is considered as a consequence of “multi-hit” processes. Osthol, a coumarin compound, has anti-inflammatory effects on various diseases. However, there is no multi-faceted and comprehensive evaluation of its effects. The current study evaluated effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.