Review
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World J Gastroenterol. Sep 7, 2014; 20(33): 11727-11735
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11727
MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer
Verena Stiegelbauer, Samantha Perakis, Alexander Deutsch, Hui Ling, Armin Gerger, Martin Pichler
Verena Stiegelbauer, Samantha Perakis, Armin Gerger, Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
Alexander Deutsch, Division of Hematology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
Hui Ling, Martin Pichler, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Author contributions: Stiegelbauer V designed research and wrote the paper; Perakis S designed research and wrote the paper; Deutsch A designed research and wrote the paper; Ling H designed research and wrote the paper; Gerger A designed research and wrote the paper; Pichler M designed research and wrote the paper.
Supported by Erwin Schroedinger Scholarship of the Austrian Science Funds, No. J3389-B23 (all to Pichler M)
Correspondence to: Martin Pichler, MD, Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. MPichler@mdanderson.org
Telephone: +43-316-3853115 Fax: +43-316-3853115
Received: January 17, 2014
Revised: April 4, 2014
Accepted: June 2, 2014
Published online: September 7, 2014
Core Tip

Core tip: In this review article, we summarize the status quo of the current literature regarding microRNAs and their role in resistance against anti-cancer drugs in colorectal cancer. This Review Article explains how microRNAs influence colorectal cancer, and how these small molecules might be useful as predictive factors and drug targets by themselves.