Advances in the management of peritoneal mesothelioma

doi:10.3748/wjg.v20.i33.11700

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 33

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11982)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

518

WORD

279

HTML

8915

Figures (1-1)

119

Tables (1-3)

123

Sum=9954

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1043

Download

985

Sum=2028

Sep 7, 2014 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (16)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Sep 7, 2014; 20(33): 11700-11712
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11700

Advances in the management of peritoneal mesothelioma

Ali Raza, Wei-Ching Huang, Kazuaki Takabe

Ali Raza, Wei-Ching Huang, Kazuaki Takabe, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0011, United States

Author contributions: All authors generated the ideas and contributed to the writing of this paper.

Supported by United States National Institute of Health, No. R01CA160688; and Susan G Komen Investigator Initiated Research Grant, No. IIR12222224 to Kazuaki Takabe

Correspondence to: Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, PO Box 980011, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu

Telephone: +1-804-8289322 Fax: +1-804-8284808

Received: December 21, 2013
Revised: March 21, 2014
Accepted: June 2, 2014
Published online: September 7, 2014

Core Tip

Core tip: Peritoneal mesothelioma (PM) historically has been associated with a very poor prognosis. Cytoreduction with hyperthermic intraperitoneal chemotherapy improved survival outcomes but carries significant morbidity. Increasingly, research has focused on identifying molecular targets and only a handful have been described; even fewer directed therapies have been evaluated. We review the role of sphingosine kinase 1 and sphingosine-1-phosphate (S1P) signaling in PM and discuss the possibility of targeting it with FTY720, a functional antagonist of S1P Receptor 1. Further investigation is warranted in this new avenue of interest.