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World J Gastroenterol. Jan 21, 2014; 20(3): 665-672
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.665
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.665
Eradication of Helicobacter pylori infection: Which regimen first?
Alessandro Federico, Antonietta Gerarda Gravina, Agnese Miranda, Carmela Loguercio, Marco Romano, Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, 80131 Naples, Italy
Author contributions: All the authors contributed to this paper equally.
Correspondence to: Marco Romano, MD, Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. marco.romano@unina2.it
Telephone: +39-815-666718 Fax: +39-815-666714
Received: September 17, 2013
Revised: November 17, 2013
Accepted: December 3, 2013
Published online: January 21, 2014
Revised: November 17, 2013
Accepted: December 3, 2013
Published online: January 21, 2014
Core Tip
Core tip: First-line therapy for Helicobacter pylori infection should have an efficacy higher than 90% to prevent the need for additional treatment and the emergence of secondary antimicrobial resistance. The first-line eradication regimen should be based on what works best in a defined geographical area and must take into account the prevalence of antimicrobial resistance in that region. Non-bismuth quadruple (i.e., concomitant) therapy appears to have high efficacy and, in our opinion, is the first choice of treatment for eradicating the infection.