Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.665
Revised: November 17, 2013
Accepted: December 3, 2013
Published online: January 21, 2014
Core tip: First-line therapy for Helicobacter pylori infection should have an efficacy higher than 90% to prevent the need for additional treatment and the emergence of secondary antimicrobial resistance. The first-line eradication regimen should be based on what works best in a defined geographical area and must take into account the prevalence of antimicrobial resistance in that region. Non-bismuth quadruple (i.e., concomitant) therapy appears to have high efficacy and, in our opinion, is the first choice of treatment for eradicating the infection.