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World J Gastroenterol. Jul 28, 2014; 20(28): 9592-9599
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9592
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9592
Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review
Crina Roman, Dan L Dumitrascu, Division of Internal Medicine, Second Medical Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
Stanislas Bruley des Varannes, Institut des Maladies de l’Appareil Digestif, University Hospital, Hotel Dieu, 44093 Nantes Cedex 01, France
Lucian Muresan, Department of Cardiology, Rehabilitation Hospital, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
Alina Picos, Faculty of Dentistry, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400023 Cluj-Napoca, Romania
Author contributions: Roman C designed and wrote the article; Bruley des Varannes S reviewed and corrected the manuscript; Muresan L contributed with suggestions and corrected the article; Picos A contributed with suggestions; Dumitrascu DL provided the idea of writing the article, contributed to the writing of the manuscript and is the guarantor of the work.
Correspondence to: Dan L Dumitrascu, MD, Professor of Medicine, Division of Internal Medicine, Second Medical Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Clinicilor Street 4-6, 400006 Cluj-Napoca, Romania. dan_dumitrascu@yahoo.de
Telephone: + 40-722-756475 Fax: +40-264-593355
Received: December 25, 2013
Revised: February 9, 2014
Accepted: April 2, 2014
Published online: July 28, 2014
Revised: February 9, 2014
Accepted: April 2, 2014
Published online: July 28, 2014
Core Tip
Core tip: The link between gastroesophageal reflux disease and atrial fibrillation is currently not understood completely. A few papers from the literature address this issue, but none has been able to draw firm conclusions. This review of the literature analyzes the potential relationship between gastroesophageal reflux disease and the development of atrial fibrillation. Five electronic databases were screened for publications on gastroesophageal reflux disease and atrial fibrillation in adults and the 8 articles found are analyzed and discussed. Although evidence on atrial fibrillation associated with gastroesophageal reflux disease exists, large randomized clinical studies are required to provide definite answers.