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World J Gastroenterol. Jul 28, 2014; 20(28): 9564-9569
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9564
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9564
Prognostic significance of nuclear hepatoma-derived growth factor expression in gallbladder cancer
Feng Tao, Min-Feng Ye, Jie-Qing Lv, Guan-Gen Xu, Yuan-Ming Jing, Wei Wang, Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Ai-Jing Sun, Department of Pathology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Author contributions: Tao F and Ye MF designed the research; Lv JQ, Xu GG and Jing YM performed the experiments; Sun AJ provided vital reagents and analytical tools; Wang W analyzed the data; and Tao F wrote the manuscript.
Correspondence to: Feng Tao, MD, Professor, Chief, Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, No. 568 Zhongxing North Road, Shaoxing 312000, Zhejiang Province, China. tf_zjsx@aliyun.com
Telephone: +86-575-88229452 Fax: +86-575-85138402
Received: January 7, 2014
Revised: March 11, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Revised: March 11, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Core Tip
Core tip: Gallbladder cancer (GBC) is a highly invasive, rapidly proliferating tumor. Unfortunately, most conventional treatments for this tumor remain associated with poor survival. Therefore, it is necessary to identify prognostic biomarkers that are independently correlated with tumor aggressiveness. This study documents hepatoma-derived growth factor (HDGF) immunostaining in gallbladder carcinomas for the first time and shows that the expression of nuclear HDGF is closely related to the carcinogenesis, clinical biological behaviors, and prognosis of GBC.