Case Control Study
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World J Gastroenterol. Jul 28, 2014; 20(28): 9534-9540
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9534
Postprandial response of bone turnover markers in patients with Crohn’s disease
Ioannis Karatzoglou, Maria P Yavropoulou, Maria Pikilidou, George Germanidis, Evangelos Akriviadis, Alexandra Papazisi, Michael Daniilidis, Pantelis Zebekakis, John G Yovos
Ioannis Karatzoglou, Maria Pikilidou, George Germanidis, Michael Daniilidis, Pantelis Zebekakis, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Maria P Yavropoulou, John G Yovos, Division of Endocrinology and Metabolism, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Evangelos Akriviadis, 4th Department of Internal Medicine, Hippokration General Hospital, 54642 Thessaloniki, Greece
Alexandra Papazisi, Department of Nuclear Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Author contributions: Yavropoulou MP and Karatzoglou I contributed equally to this study; Yavropoulou MP and Karatzoglou I designed and performed the research; Germanidis G and Pikilidou M analyzed the data; Akriviadis E and Daniilidis M contributed the analytic tools; Papazisi A performed all assays, and Yavropoulou MP and Yovos JG wrote the paper; Daniilidis M, Zebekakis P, Akriviadis E and Germanidis G revised the final draft.
Correspondence to: Maria P Yavropoulou, MD, PhD, Endocrinologist, Division of Endocrinology and Metabolism, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 S Kyriakidi Street, 54636 Thessaloniki, Greece. margia@med.auth.gr
Telephone: +30-2-310993187 Fax: +30-2-310994608
Received: September 25, 2013
Revised: March 6, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Core Tip

Core tip: Serum C-terminal crosslinking telopeptide of type I collagen is significantly higher in patients with Crohn’s disease (CD) compared to controls and values are significantly correlated with the activity of the disease, reflecting probably the increased osteoclastogenesis induced by the secretion of inflammatory cytokines. Despite higher bone turnover, however, the physiological skeletal response of postprandial suppression of bone resorption is maintained in patients with CD but is strongly dependent to the activity of the disease.