Research Report
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World J Gastroenterol. Jul 28, 2014; 20(28): 9513-9518
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9513
Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice
Guo-Qiang Xu, Cheng-Fu Xu, Hong-Tan Chen, Shan Liu, Xiao-Dong Teng, Gen-Yun Xu, Chao-Hui Yu
Guo-Qiang Xu, Cheng-Fu Xu, Hong-Tan Chen, Shan Liu, Chao-Hui Yu, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Xiao-Dong Teng, Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Gen-Yun Xu, Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Xu GQ, Xu CF, Chen HT and Yu CH designed the research; Xu GQ, Xu CF, Chen HT, Liu S, Teng XD, Xu GY and Yu CH performed the research; Xu GQ, Xu CF, Chen HT and Liu S analyzed the data; and Xu GQ and Xu CF wrote the paper.
Supported by National Natural Science Foundation of China, No. 81070366
Correspondence to: Guo-Qiang Xu, MD, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyxgq@sina.cn
Telephone: +86-571-87236518 Fax: +86-571-87236611
Received: January 13, 2014
Revised: March 19, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Core Tip

Core tip: Cholesterol gallstone disease (CGD) is one of the most common digestive diseases worldwide, while the mechanisms of this disease are not fully understood. In this study, we established a mouse model of CGD and observed that the formation of gallstones was accompanied by an increase in serum and bile total cholesterol concentrations, while by a decrease in total bile acid concentration in bile. The formation of gallstones was also accompanied by downregulation of hepatic caveolin-3 (CAV3) expression, and downregulation of CAV3 and cholecystokinin A receptor (CCKAR) expression in the gallbladder. Our results suggest that CAV3 and CCKAR may be involved in CGD.