Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9458
Revised: February 15, 2014
Accepted: June 2, 2014
Published online: July 28, 2014
Core tip: Ulcerative colitis has gained importance over the past few decades due to its increasing incidence rate worldwide. This condition is a chronic disease that affects quality of life, and it can lead to death if not treated properly. Over the past few decades, advances in treatment have provided benefits for patients, including a reduction in mortality. Due to phenotypic variability, different therapeutic modalities may be used. It is important to recognize the factors associated with a more severe clinical course so that clinical decisions can be made as early as possible.