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World J Gastroenterol. Jul 28, 2014; 20(28): 9261-9269
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9261
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9261
Cytokinome profile evaluation in patients with hepatitis C virus infection
Francesca Capone, Eliana Guerriero, Giuseppe Castello, Susan Costantini, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori “Fondazione Giovanni Pascale”, IRCCS, 83013 Mecogliano, Italy
Giovanni Colonna, Biochemistry, Biophysics and General Pathology Department, Second University of Naples, 80100 Naples, Italy
Patrizia Maio, Department of Infectious Diseases, “San Giuseppe Moscati” Hospital, 83100 Avellino, Italy
Alessandra Mangia, Liver Unit, IRCCS Casa SollievodellaSofferenza Hospital, 71013 San Giovanni Rotondo, Italy
Author contributions: Capone F, Guerriero E, Colonna G, Castello G and Costantini S designed the experiments; Maio P and Mangia A enrolled patients; Capone F, Guerriero E and Costantini S performed the experiments and data analysis; Capone F, Guerriero E, Colonna G and Costantini S wrote the paper; all of the authors read and approved the final version of the manuscript.
Correspondence to: Susan Costantini, PhD, Centro Ricerche Oncologiche di Mercogliano, IstitutoNazionale per lo Studio e la CuradeiTumori “Fondazione Giovanni Pascale”, IRCCS, Via AmmiraglioBianco, 83013 Mercoglicano, Italy. s.costantini@istitutotumori.na.it
Telephone: +39-825-1911730 Fax: +39-825-1911705
Received: October 22, 2013
Revised: February 20, 2014
Accepted: April 30, 2014
Published online: July 28, 2014
Revised: February 20, 2014
Accepted: April 30, 2014
Published online: July 28, 2014
Core Tip
Core tip: In this review we report the usefulness of cytokinome profiling in improving our understanding of the role cytokines play in the evolution of chronic inflammatory processes leading to cancer. The serum levels of cytokines were evaluated in patients with hepatitis C virus infection-related liver diseases in the presence and absence of either hepatocellular carcinoma or type 2 diabetes. In addition, the complex interaction network, between the significant cytokines and their metabolic pathways, was studied using bioinformatics and systems biology approaches.