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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2014; 20(27): 9191-9199
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9191
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9191
Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature
Xiao Du, Zhong Cheng, Yi-Han Wang, Zi-Heng Guo, Si-Qin Zhang, Jian-Kun Hu, Zong-Guang Zhou, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Du X and Wang YH performed the majority of this work; Cheng Z performed the research; Guo ZH and Zhang SQ were involved in editing the manuscript; Hu JK and Zhou ZG designed the study and revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81071777; and Sichuan Province Science and Technology Support Program, No. 2011SZ0293 and No. 2011SZ0087
Correspondence to: Jian-Kun Hu, Professor, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. hujkwch@126.com
Telephone: +86-28-85422872 Fax: +86-28-85422484
Received: January 17, 2014
Revised: February 27, 2014
Accepted: April 30, 2014
Published online: July 21, 2014
Revised: February 27, 2014
Accepted: April 30, 2014
Published online: July 21, 2014
Core Tip
Core tip: This article quantitatively summarizes the evidence for the association between Notch signaling pathway and gastric cancer (GC) by meta-analysis, and finds that Notch1 and Notch2 signaling pathways have been activated in GC; increased expression of Notch1 is associated with non-cardia location, > 5 cm size, diffuse type, positive lymphovascular invasion and distal metastasis; Notch1 and Jagged1 may be independent poor prognostic predictors in GC. Notch signaling may participate in tumor formation and progression of GC.