Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2014; 20(27): 8957-8963
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8957
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8957
Helicobacter pylori and functional dyspepsia: An unsolved issue?
Angelo Zullo, Cesare Hassan, Gastroenterology and Digestive Endoscopy, “Nuovo Regina Margherita” Hospital, 00153 Rome, Italy
Vincenzo De Francesco, Gastroenterology Unit, “Riuniti” Hospital, 24128 Foggia, Italy
Alessandro Repici, Digestive Endoscopy Unit, “IRCCS Istituto Clinico Humanitas”, 20089 Milan, Italy
Raffaele Manta, Gastroenterology and Endoscopy Unit, “Nuovo S Agostino” Hospital, 41100 Modena, Italy
Silverio Tomao, Oncology Unit, “SM Goretti” Hospital, Latina, “Sapienza” University, 00185 Rome, Italy
Bruno Annibale, Department of Digestive and Liver Diseases, “Sant’Andrea” Hospital, “Sapienza” University, 00185 Rome, Italy
Dino Vaira, Department of Internal Medicine and Gastroenterology, University of Bologna, 40126 Bologna, Italy
Author contributions: Zullo A and Hassan C designed research; De Francesco V, Repici A and Manta R performed research; Tomao S, Annibale B and Vaira D contributed with constructive criticisms; Zullo A and Hassan C analyzed data and wrote the paper.
Correspondence to: Angelo Zullo, MD, Gastroenterology and Digestive Endoscopy, “Nuovo Regina Margherita” Hospital, Via E Morosini 30, 00153 Roma, Italy. zullo66@yahoo.it
Telephone: +39-6-58446608 Fax: +39-6-58446533
Received: November 16, 2013
Revised: December 30, 2013
Accepted: April 2, 2014
Published online: July 21, 2014
Revised: December 30, 2013
Accepted: April 2, 2014
Published online: July 21, 2014
Core Tip
Core tip: The role of Helicobacter pylori infection in functional dyspesia is still controversial. Some meta-analyses indicated the infection eradication is associated with a significant therapeutic gain as compared to placebo. However, the considered trials differ for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Therefore, further studies are needed.