Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2014; 20(27): 8947-8956
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8947
Fluoroquinolone-based protocols for eradication of Helicobacter pylori
Antonio Rispo, Pietro Capone, Fabiana Castiglione, Luigi Pasquale, Matilde Rea, Nicola Caporaso
Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University “Federico II” of Naples, 80131 Napoli, Italy
Luigi Pasquale, Division of Gastroenterology, P.O. “Sant’Ottone Frangipane”, Ariano Irpino, 80131 Napoli, Italy
Author contributions: Rispo A wrote the article; Capone P and Rea M identified the articles by Medline search; Castiglione F and Pasquale L reviewed the papers; Caporaso N contributed to critical revision of the manuscript.
Correspondence to: Antonio Rispo, MD, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University “Federico II” of Naples, Via S. Pansini 5, 80131 Napoli, Italy. antoniorispo@email.it
Telephone: +39-81-7463849 Fax: +39-81-5465649
Received: September 4, 2013
Revised: February 10, 2014
Accepted: April 1, 2014
Published online: July 21, 2014
Processing time: 320 Days and 16.8 Hours
Core Tip

Core tip: The Maastricht IV consensus, which focused on the management of Helicobacter pylori (H. pylori) infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. The aim of the present invited paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.