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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2014; 20(27): 8859-8866
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8859
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8859
Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions
Niall P Hyland, Eamonn MM Quigley, Elizabeth Brint, Alimentary Pharmabiotic Centre, University College Cork, 30 Cork, Ireland
Niall P Hyland, Department of Pharmacology and Therapeutics, University College Cork, 30 Cork, Ireland
Eamonn MM Quigley, Houston Methodist Hospital, Houston, TX 77030, United States
Elizabeth Brint, Department of Pathology, University College Cork, 30 Cork, Ireland
Author contributions: Hyland NP and Quigley EMM contributed equally to this manuscript; all the authors approved the final version.
Correspondence to: Elizabeth Brint, PhD, Department of Pathology, University College Cork, Coláiste Na Hollscoile, Bóthar an Choláiste, Co. Corcaigh, 30 Cork, Ireland. e.brint@ucc.ie
Telephone: +353-21-4205045
Received: November 27, 2013
Revised: March 19, 2014
Accepted: May 12, 2014
Published online: July 21, 2014
Revised: March 19, 2014
Accepted: May 12, 2014
Published online: July 21, 2014
Core Tip
Core tip: Recent discoveries have kindled an interest in microbiota-host interactions in irritable bowel syndrome (IBS) and have led to new lines of research into this common and elusive disorder. It is clear that the microbiota is altered in IBS and that such alterations could well contribute to the pathogenesis of the disorder through, for example, increased permeability, an altered immune profile, effects on the central nervous system and modulation of gut neuromuscular function. This review will explore these host-microbe interactions and their relevance to the pathogenesis of IBS. This review will explore these interactions and their relevance to the pathogenesis of IBS.