Joshi RK, Kim WJ, Lee SA. Association between obesity-related adipokines and colorectal cancer: A case-control study and meta-analysis. World J Gastroenterol 2014; 20(24): 7941-7949 [PMID: 24976730 DOI: 10.3748/wjg.v20.i24.7941]
Corresponding Author of This Article
Sang-Ah Lee, PhD, Department of Preventive Medicine, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, South Korea. sangahlee@kangwon.ac.kr
Research Domain of This Article
Public, Environmental & Occupational Health
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
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World J Gastroenterol. Jun 28, 2014; 20(24): 7941-7949 Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7941
Association between obesity-related adipokines and colorectal cancer: A case-control study and meta-analysis
Rakhi Kumari Joshi, Woo Jin Kim, Sang-Ah Lee
Rakhi Kumari Joshi, Sang-Ah Lee, Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-701, South Korea
Woo Jin Kim, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do 200-701, South Korea
Author contributions: Lee SA designed the research, contributed to writing the manuscript, assisted in revisions to approved the final version of the manuscript; Kim WJ provided the blood samples and contributed to approve the final version of manuscript; Joshi RK performed the statistical analysis and wrote the manuscript.
Supported by Korean Ministry of Health and Welfare through the National R and C Program of Cancer Control (1020420); and 2010 Research Grant from Kangwon National University
Correspondence to: Sang-Ah Lee, PhD, Department of Preventive Medicine, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, South Korea. sangahlee@kangwon.ac.kr
Telephone: +82-33-2558871 Fax: +82-33-2508809
Received: October 25, 2013 Revised: January 24, 2014 Accepted: April 8, 2014 Published online: June 28, 2014
Core Tip
Core tip: Evidence from the previous studies indicates that there is an association of obesity-related adipokines and pro-inflammatory cytokines with colorectal cancer risk, but the results are inconsistent. In this study, a case-control study and meta-analysis were performed to investigate the possible association of adipokines (adiponectin, leptin, and resistin) and pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α) with colorectal cancer risk. Although we did not find any significant results, case-control study and meta-analysis results support a previous report and suggest that obesity-related adipokines could be risk factors for colorectal cancer; however, further studies with larger number of prospective approaches are needed.
