Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7686
Revised: January 1, 2014
Accepted: May 23, 2014
Published online: June 28, 2014
Core tip: Patients receiving nucleos(t)ide analog (NA) treatment typically exhibit slow declines in serum hepatitis B surface antigen (HBsAg), with many patients requiring decades of treatment to achieve HBsAg clearance. However, a low baseline HBsAg level or a rapid reduction in HBsAg during NA therapy may identify patients who will show HBsAg clearance, and predict virological response or hepatitis B e antigen (HBeAg) loss/seroconversion in HBeAg-positive patients. Viral breakthrough due to drug resistance can increase HBsAg titers. Among Asian patients, HBsAg levels of < 100-200 IU/mL at the end of treatment may predict lower risk of hepatitis B virus relapse and cessation of treatment can be considered in HBeAg-negative patients.