Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7518
Revised: February 22, 2014
Accepted: April 8, 2014
Published online: June 21, 2014
Core tip: Cronkhite-Canada syndrome (CCS) is a rare noncongenital gastrointestinal polyposis syndrome, characterized by skin hyperpigmentation, hair loss and nail atrophy, associated with high morbidity. This case report summarizes the characteristics of six CCS patients, and reviews the literature. Comprehensive treatment led by corticosteroids can improve prognosis, and long-term follow-up is necessary.